Curriculum Vitae

Gabriella Miklóssy, PhD – Biochemist and Molecular Biologist – Gabriella’s LinkedIn profile

Professional History

Arvinas, Inc., New Haven, CT, USA (2019 – present)

  • Senior Research Investigator, 2022 – present

Leading DEL and display selections to discover unique small molecule and peptide binders supporting Arvinas’ various drug discovery programs

  • Research Investigator, 2019 – 2022

Screened DNA-encoded chemical libraries against therapeutically important proteins to find drug candidates.

Baylor College of Medicine Center for Drug Discovery, Houston, TX, USA (2016 – 2019)

  • Staff Scientist

Screened DNA-encoded chemical libraries against therapeutically important proteins to find drug candidates.

Natural Products and Experimental Therapeutics Program, University of Hawaii Cancer Center, Honolulu, HI, USA (2012 – 2016)

  • Project Manager – Senior Postdoctoral Researcher

Interested in discovering natural product-based novel anticancer drugs targeting STAT3 signaling.

Division of Rheumatology, Department of Medicine, State University of New York, Upstate Medical University, Syracuse, NY, USA (2009 – 2012)

  • Postdoctoral Researcher

Focused on the biochemistry of transaldolase and HRES1/Rab4 for better understanding of the pathophysiology of Systemic Lupus Erythematosus.

Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary (2002 – 2008)

  • PhD Student and Junior Research Fellow

Designed dominant negative HIV-1 protease inhibitors and tested their activity using a novel high-throughput microtiter plate fluorescent assay.

InnoTears Ltd., Debrecen, Hungary (2006 – 2008)

  • Research Scientist

Worked on the recombinant plasminogen activator inhibitor-2 fusion peptide production and usage in corneal ulcer treatment as an eye-drop. This idea was patented in 2009.

Qualifications

PhD, Biomedical Sciences, (Summa cum laude), 2008

University of Debrecen, Hungary

MSc, Biologist / Biochemist, 2002

University of Debrecen, Hungary

Skills and Techniques

  • DNA-encoded library affinity selection and supporting processes in drug discovery
  • DNA and RNA purification, cloning, site-directed mutagenesis, PCR, quantitative RT-PCR
  • protein engineering, expression, purification and characterization of recombinant proteins (gelfiltration, HPLC, FPLC, AKTA operation), western blot, ELISA
  • cell culturing, blood cell separation, transfection, recombinant virus expression, gene silencing (siRNA), flow cytometry analysis, immunofluorescence staining
  • assay developement, luciferase assay, electrophoretic mobility shift assay (EMSA), fluorescence polarization (FP) assay, surface plasmone resonance (SPR) analysis
  • in vitro tumor biology assays: cell viability and migration assays
  • in vivo tumor biology assay: xenograft mouse model

Patents

Tőzsér, J., Berta, A., Csutak, A., Miklóssy, G. (2009) Use of Urokinase Type Plasminogen Activator Inhibitors for the Treatment of Corneal Disorders. EP Patent EP2224949 B1

Tőzsér, J., Berta, A., Csutak, A., Miklóssy, G. (2011) Use of Urokinase Type Plasminogen Activator Inhibitors for the Treatment of Corneal Disorders. US Patent Application 20110028397 A1

Publications

Click here to see the full list of Gabriella Miklóssy’s publications or visit her Google Scholar profile.